Metabolic engineering of Yarrowia lipolytica for thermoresistance and enhanced erythritol productivity

Abstract

The strategy developed herein yielded an engineered <i>Y. lipolytica</i> strain with enhanced thermoresistance and NADPH supply, resulting in a higher ability to produce erythritol, but not mannitol or d-arabitol from glucose. This is of interest for process development since it will reduce the cost of bioreactor cooling and erythritol purification.