NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington's disease mouse model

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh et al. · Genes & Development · 1999 · 3.6K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.

Paolo Moi, Isadora Asunis, Antonio Cao et al. · Proceedings of the National Academy of Sciences · 1994 · 1.6K citations

Life Sciences, Genetics, Molecular Biology +17

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

Donna D. Zhang, Mark Hannink · Molecular and Cellular Biology · 2003 · 1.4K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13

Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression

Michael McMahon, Ken Itoh, Masayuki Yamamoto et al. · Journal of Biological Chemistry · 2003 · 1.1K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +12

Keap1 regulates both cytoplasmic‐nuclear shuttling and degradation of Nrf2 in response to electrophiles

Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh et al. · Genes to Cells · 2003 · 822 citations

Life Sciences, Cell Biology, Molecular Biology +14