Concepedia

ICOSL <sup>+</sup> plasmacytoid dendritic cells as inducer of graft-versus-host disease, responsive to a dual ICOS/CD28 antagonist

Djamilatou Adom, Stacey R. Dillon, Jinfeng Yang, Hao Liu, Abdulraouf Ramadan, Kushi Kushekhar, Samantha Hund, A. Leland Albright, Maykala Kirksey, Titilayo Adeniyan,

Science Translational Medicine · 2020 · 26 citations · 33 references

DOIFull text

Open access

Concepts

Abstract

-pDCs as an aGVHD biomarker and suggest that coinhibition of the ICOSL/ICOS and B7/CD28 axes with one biologic drug may represent a therapeutic opportunity to prevent or treat aGVHD.

References

33

Prevention of Graft Versus Host Disease by Inactivation of Host Antigen-Presenting Cells

Warren D. Shlomchik, Matthew S. Couzens, Cheng Bi Tang et al. · Science · 1999 · 1.2K citations

, , +16

An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin

KR Cooke, Lester Kobzik, TR Martin et al. · Blood · 1996 · 986 citations · Full text

, , +8

ST2 as a Marker for Risk of Therapy-Resistant Graft-versus-Host Disease and Death

Mark T. Vander Lugt, Thomas Braun, Samir Hanash et al. · New England Journal of Medicine · 2013 · 399 citations · Full text

, , +12

STAT3 Is Required for Flt3L-Dependent Dendritic Cell Differentiation

Yasmina Laouar, Thomas Welte, Xin-Yuan Fu et al. · Immunity · 2003 · 328 citations · Full text

, , +11

Donor APCs are required for maximal GVHD but not for GVL

Catherine C. Matte, Jinli Liu, James Cormier et al. · Nature Medicine · 2004 · 317 citations

, , +10