Increased Tumoral Microenvironmental pH Improves Cytotoxic Effect of Pharmacologic Ascorbic Acid in Castration-Resistant Prostate Cancer Cells

Abstract

The alkalinity of tumor microenvironment plays an important role in anticancer efficiency of AA in CRPC. ¹⁸F-DFA PET/CT imaging could predict the therapeutic response of PCa animal model through illustration of tumoral uptake of AA. ¹⁸F-DFA might be a potential PET tracer in clinical diagnosis and treatment for CRPC.