Concepedia

The GABAB receptor positive allosteric modulator COR659: In vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives

Francesca Ferlenghi, Paola Maccioni, Claudia Mugnaini, Antonella Brizzi, Federica Fara, Rafaela Mostallino, M. Paola Castelli, Giancarlo Colombo, Marco Mor, Federica Vacondio,

European Journal of Pharmaceutical Sciences · 2020 · 14 citations · 25 references

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Concepts

References

25

3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain

David R. Hill, Norman G. Bowery · Nature · 1981 · 1K citations

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THE IMPACT OF P-GLYCOPROTEIN ON THE DISPOSITION OF DRUGS TARGETED FOR INDICATIONS OF THE CENTRAL NERVOUS SYSTEM: EVALUATION USING THE MDR1A/1B KNOCKOUT MOUSE MODEL

Angela C. Doran, R. Scott Obach, Bill J. Smith et al. · Drug Metabolism and Disposition · 2004 · 440 citations

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Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501.

Stephan Urwyler, Johannes Mosbacher, Kurt Lingenhoehl et al. · PubMed · 2001 · 239 citations

, , +17

Positive Allosteric Modulation of Native and Recombinant γ-Aminobutyric Acid<sub>B</sub>Receptors by 2,6-Di-<i>tert</i>-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its Aldehyde Analog CGP13501

Stephan Urwyler, Johannes Mosbacher, Kurt Lingenhoehl et al. · Molecular Pharmacology · 2001 · 218 citations

, , +17

N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and Structurally Related Compounds: Novel Allosteric Enhancers of γ-Aminobutyric AcidB Receptor Function

Stephan Urwyler, Mario F. Pozza, Kurt Lingenhoehl et al. · Journal of Pharmacology and Experimental Therapeutics · 2003 · 183 citations · Full text

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