Study of mitophagy and ATP-related metabolomics based on β-amyloid levels in Alzheimer's disease

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

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Alzheimer's Disease, Dementia, Biomarkers +10

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

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Cell Autophagy, Mitophagy, Mitochondrial Function +11

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

Derek P. Narendra, Seok Min Jin, Atsushi Tanaka et al. · PLoS Biology · 2010 · 2.8K citations · Full text

Pink1 Accumulation, Mitophagy, Activate Parkin +18

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

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Cell Autophagy, Mitophagy, Ubiquitin Kinase Pink1 +9

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

F. Michael Yakes, Bennett Van Houten · Proceedings of the National Academy of Sciences · 1997 · 1.8K citations · Full text