Concepedia

Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma

Jonas Ecker, Venu Thatikonda, Gianluca Sigismondo, Florian Selt, Gintvile Valinciute, Ina Oehme, Carina Müller, Juliane L. Buhl, Johannes Ridinger, Diren Usta,

Neuro-Oncology · 2020 · 61 citations · 19 references

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Open access

Abstract

Our data elucidate the molecular interaction of MYC and HDAC2 and support a model in which inhibition of class I HDACs directly targets MYC's transactivating and transrepressing functions.

References

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