Molecular signatures database (MSigDB) 3.0

TLDR

Well‑annotated gene sets covering the full range of biological processes are essential for interpreting large‑scale genomic data, and the Molecular Signatures Database (MSigDB) is a widely used repository of such sets. MSigDB 3.0 now offers more than 6,700 gene sets, a complete overhaul of canonical pathways and experimental signatures, enhanced annotations, and upgraded website features. MSigDB 3.0 is freely available for non‑commercial use at http://www.broadinstitute.org/msigdb; contact [e-mail].

Abstract

Abstract Motivation: Well-annotated gene sets representing the universe of the biological processes are critical for meaningful and insightful interpretation of large-scale genomic data. The Molecular Signatures Database (MSigDB) is one of the most widely used repositories of such sets. Results: We report the availability of a new version of the database, MSigDB 3.0, with over 6700 gene sets, a complete revision of the collection of canonical pathways and experimental signatures from publications, enhanced annotations and upgrades to the web site. Availability and Implementation: MSigDB is freely available for non-commercial use at http://www.broadinstitute.org/msigdb. Contact: [e-mail]