Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

Ben Langmead, Cole Trapnell, Mihai Pop, +1

Genome biology

Model-based Analysis of ChIP-Seq (MACS)

Yong Zhang, Tao Liu, Clifford A. Meyer, +8

Genome biology

Fitting a mixture model by expectation maximization to discover motifs in biopolymers.

Trisha L. Bailey, Charles Elkan

PubMed

More MotifsEngineeringPattern DiscoveryPattern MiningGene Recognition +20

NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins

Kim D. Pruitt, Tatiana Tatusova, D. R. Maglott

Nucleic Acids Research

BiologyReference SequenceRefseq RecordsBiological DatabaseBioinformatics Database +10

Histone H3K27ac separates active from poised enhancers and predicts developmental state

Menno P. Creyghton, Albert W. Cheng, G. Grant Welstead, +10

Proceedings of the National Academy of Sciences

Histone ModificationsEpigenetic ChangeGeneticsEpigeneticsDevelopmental Programs +18

The landscape of somatic copy-number alteration across human cancers

Rameen Beroukhim, Craig H. Mermel, Dale Porter, +59

Nature

Somatic VariantTumor HeterogeneityMedicinePathologySomatic Copy-number Alteration +5

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Jake Delmore, Ghayas C. Issa, Madeleine E. Lemieux, +21

Cell

MedicineImmunologyTherapeutic EfficacyBiological TherapyBet Bromodomain Inhibition +5

Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells

Xi Chen, Xu Han, Ping Yuan, +20

Cell

Transcriptional RegulationSystems BiologyDevelopmental BiologyCell LineageCore Transcriptional Network +12

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

Amy E. Pasquinelli, Brenda J. Reinhart, Frank J. Slack, +16

Nature

Developmental BiologyGeneticsRna BiologyLong Non-coding RnaTemporal Expression +6

A unique chromatin signature uncovers early developmental enhancers in humans

Álvaro Rada-Iglesias, Ruchi Bajpai, Tomek Swigut, +3

Nature

ChromatinDevelopmental BiologyChromatin RemodelingEpigenetic ChangeGenetics +6