Concepedia

Targeting the kinase insert loop of PERK selectively modulates PERK signaling without systemic toxicity in mice

Daniel T. Hughes, Mark Halliday, Heather Smith, Nicholas Verity, Colin Molloy, Helois Radford, Adrian J. Butcher, Giovanna R. Mallucci

Science Signaling · 2020 · 24 citations · 36 references

DOI

Concepts

Abstract

to partially down-regulate PERK-eIF2α signaling while avoiding widespread ISR inhibition may be a safe therapeutic approach in neurodegenerative disease.

References

36

MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs <i>In vitro</i> and <i>In vivo</i>

Hiroshi Hirai, Hiroshi Sootome, Yoko Nakatsuru et al. · Molecular Cancer Therapeutics · 2010 · 938 citations · Full text

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Depleting Neuronal PrP in Prion Infection Prevents Disease and Reverses Spongiosis

Giovanna R. Mallucci, Andrew Dickinson, Jacqueline M. Linehan et al. · Science · 2003 · 760 citations

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Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism

Xiaolin Wan, B Harkavy, Patrick J. Grohar et al. · Oncogene · 2006 · 747 citations

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Pharmacological brake-release of mRNA translation enhances cognitive memory

Carmela Sidrauski, Diego Acosta‐Alvear, Arkady Khoutorsky et al. · eLife · 2013 · 743 citations · Full text

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The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

Carmela Sidrauski, Anna McGeachy, Nicholas T. Ingolia et al. · eLife · 2015 · 665 citations · Full text

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