Highly regio- and enantio-selective hydrolysis of two racemic epoxides by GmEH3, a novel epoxide hydrolase from Glycine max

A simple method to determine the enantiomeric ratio in enantioselective biocatalysis

J. L. L. Rakels, Adrie J. J. Straathof, Joseph J. Heijnen · Enzyme and Microbial Technology · 1993 · 228 citations

Engineering, Biotechnology, Chemistry +16

Structure of Human Epoxide Hydrolase Reveals Mechanistic Inferences on Bifunctional Catalysis in Epoxide and Phosphate Ester Hydrolysis^,

G. Gomez, Christophe Morisseau, Bruce D. Hammock et al. · Biochemistry · 2004 · 184 citations

Life Sciences, Biochemistry, Biology +17

Structure of Aspergillus niger epoxide hydrolase at 1.8 Å resolution: implications for the structure and function of the mammalian microsomal class of epoxide hydrolases

Jinyu Zou, B.M. Hallberg, Terese Bergfors et al. · Structure · 2000 · 181 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

Directed Evolution of an Enantioselective Epoxide Hydrolase: Uncovering the Source of Enantioselectivity at Each Evolutionary Stage

Manfred T. Reetz, Marco Bocola, Li-Wen Wang et al. · Journal of the American Chemical Society · 2009 · 151 citations · Full text

Life Sciences, Biochemistry, Chemistry +17

Discovery of a 1<i>H</i>-Benzoimidazol-2-yl)-1<i>H</i>-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity

Mark D. Wittman, Joan M. Carboni, Ricardo M. Attar et al. · Journal of Medicinal Chemistry · 2005 · 135 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11