Concepedia

Seeking Nonspecific Binding: Assessing the Reliability of Tissue Dilutions for Calculating Fraction Unbound

William J. Jusko, Emilie A.G. Molins, Vivaswath S. Ayyar

Drug Metabolism and Disposition · 2020 · 20 citations · 41 references

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Concepts

References

41

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach · Drug Metabolism and Disposition · 1999 · 1.2K citations

, , +17

Physiologically based pharmacokinetic modelling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions

Trudy Rodgers, Malcolm Rowland · Journal of Pharmaceutical Sciences · 2006 · 940 citations

, , +11

Lipid composition of the normal human brain: gray matter, white matter, and myelin

John S. O’Brien, Elizabeth L Sampson · Journal of Lipid Research · 1965 · 861 citations · Full text

, , +15

General Pharmacokinetic Model for Drugs Exhibiting Target-Mediated Drug Disposition

Donald E. Mager, William J. Jusko · Journal of Pharmacokinetics and Pharmacodynamics · 2001 · 587 citations

, , +14

A Priori Prediction of Tissue:Plasma Partition Coefficients of Drugs to Facilitate the Use of Physiologically‐Based Pharmacokinetic Models in Drug Discovery

Patrick Poulin, Frank‐Peter Theil · Journal of Pharmaceutical Sciences · 2000 · 423 citations

, , +8