Theranostics · 2020 · 338 citations · 44 references
Life SciencesNeurobiologyNeuroscienceInnate ImmunityMolecular NeuroscienceNeuroimmunologyAcute Ischemic StrokeInflammatory SignalingMicroglia BiologyNeuroinflammationNeuroprotectionStrokeCyclic Gmp-amp Synthase SignalingInterferon-induced GenesInterferon-stimulated GenesIschemic Stroke PathophysiologyMicroglial Innate Immune SignalingMicroglial Responses To InjuryNeuroinflammation In StrokeNeuroinflammation Modulation
Collectively, we elucidated that the HDAC3-p65-cGAS-STING pathway is involved in the development of I/R-induced neuroinflammation, identifying a new therapeutic avenue for the treatment of ischemic stroke.
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Medicine, Neuroscience, Surgery +17
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cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
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