Concepedia

Exosomes derived from GDNF-modified human adipose mesenchymal stem cells ameliorate peritubular capillary loss in tubulointerstitial fibrosis by activating the SIRT1/eNOS signaling pathway

Lu Chen, Yanping Wang, Shulin Li, Bangjie Zuo, Xiangyu Zhang, Fengzhen Wang, Dong Sun

Theranostics · 2020 · 139 citations · 42 references

DOIFull text

Open access

Concepts

Abstract

Our study unveiled a mechanism by which exosomes ameliorate renal fibrosis: GDNF-AMSC-exos may activate an angiogenesis program in surviving PTCs after injury by activating the SIRT1/eNOS signaling pathway.

References

42

Chronic Kidney Disease and the Risks of Death, Cardiovascular Events, and Hospitalization

Alan S. Go, Glenn M. Chertow, Dongjie Fan et al. · New England Journal of Medicine · 2004 · 11.4K citations · Full text

, , +14

miR-126 Regulates Angiogenic Signaling and Vascular Integrity

Jason E. Fish, Massimo Santoro, Sarah U. Morton et al. · Developmental Cell · 2008 · 1.7K citations · Full text

, , +11

Mesenchymal Stem Cell-Derived Microvesicles Protect Against Acute Tubular Injury

Stefania Bruno, Cristina Grange, Maria Chiara Deregibus et al. · Journal of the American Society of Nephrology · 2009 · 1.3K citations · Full text

, , +12

Origin and function of myofibroblasts in kidney fibrosis

Valerie S. LeBleu, Gangadhar Taduri, Joyce T. O’Connell et al. · Nature Medicine · 2013 · 1.2K citations · Full text

, , +12

Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

Donald G. Phinney, Michelangelo Di Giuseppe, Joel Njah et al. · Nature Communications · 2015 · 999 citations · Full text

, , +17