Concepedia

Hsp90 inhibitor HSP990 in very low dose upregulates EAAT2 and exerts potent antiepileptic activity

Longze Sha, Ting Chen, Yu Deng, Tingfu Du, Kaili Ma, Wanwan Zhu, Yan Shen, Qi Xu

Theranostics · 2020 · 24 citations · 30 references

DOIFull text

Open access

Concepts

Abstract

These results support further preclinical studies of HSP990 treatment for temporal lobe epilepsy.

References

30

Incidence and impact of subclinical epileptiform activity in Alzheimer's disease

Keith Vossel, Kamalini G. Ranasinghe, Alexander J. Beagle et al. · Annals of Neurology · 2016 · 541 citations

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Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse model with diabetes

Shuko Takeda, Naoyuki Sato, Kozue Uchio‐Yamada et al. · Proceedings of the National Academy of Sciences · 2010 · 505 citations · Full text

, , +17

Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease

Alice Lam, Gina Deck, Alica M. Goldman et al. · Nature Medicine · 2017 · 379 citations · Full text

, , +14

Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action

G Elif Karagöz, Afonso M.S. Duarte, Elias Akoury et al. · Cell · 2014 · 329 citations · Full text

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Hippocampal interictal epileptiform activity disrupts cognition in humans

Jonathan K. Kleen, Rod C. Scott, Gregory L. Holmes et al. · Neurology · 2013 · 269 citations

, , +16