The Mouseion at the JAXlibrary (Jackson Laboratory) · 2007 · 1K citations · 9 references
PharmacyBiomedical SciencesTranslational SciencesTranslational MedicineBench-to-bedside ResearchHumanized Animal ModelsPreclinical ResearchHumanized Disease ModelsHumanized ModelsHumanized Mouse Models
The culmination of decades of research on humanized mice is leading to advances in our understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity, infectious diseases, cancer biology and regenerative medicine. In this Review, we discuss the development of these new generations of humanized mice, how they will facilitate translational research in several biomedical disciplines and approaches to overcome the remaining limitations of these models.
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