Concepedia

Synthesis of pyrazolone fused benzodiazepines <i>via</i> Rh(<scp>iii</scp>)-catalyzed [4 + 3] annulation of 1-phenylpyrazolidinones with propargyl alcohols

Linghua Zhang, Yuanshuang Xu, Xiaopeng Zhang, Xiaopeng Zhang, Xinying Zhang, Xinying Zhang, Xuesen Fan

Organic Chemistry Frontiers · 2020 · 63 citations · 38 references

DOI

Concepts

Abstract

An efficient synthesis of pyrazolone fused benzodiazepines through an unprecedented regioselective [4 + 3] annulation of 1-phenylpyrazolidinones with propargyl alcohols <italic>via</italic> Rh(<sc>iii</sc>)-catalyzed redox-neutral C–H/N–H/C–O bond activation is presented.

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