Concepedia

Nicotine Modulates CTSS (Cathepsin S) Synthesis and Secretion Through Regulating the Autophagy-Lysosomal Machinery in Atherosclerosis

Huaner Ni, Shuang Xu, Hangwei Chen, Qiuyan Dai

Arteriosclerosis Thrombosis and Vascular Biology · 2020 · 25 citations · 34 references

DOIFull text

Open access

Abstract

We concluded that nicotine mediates CTSS synthesis and secretion through regulating the autophagy-lysosomal machinery, which offers a potential therapeutic target for atherosclerosis treatment.

References

34

TFEB Links Autophagy to Lysosomal Biogenesis

Carmine Settembre, Chiara Di Malta, Vinicia Assunta Polito et al. · Science · 2011 · 3.1K citations · Full text

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

Carmine Settembre, Roberto Zoncu, Diego L. Medina et al. · The EMBO Journal · 2012 · 1.9K citations · Full text

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Termination of autophagy and reformation of lysosomes regulated by mTOR

Li Yu, Christina McPhee, Lixin Zheng et al. · Nature · 2010 · 1.5K citations · Full text

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A unifying model for mTORC1-mediated regulation of mRNA translation

Carson C. Thoreen, Lynne Chantranupong, Heather R. Keys et al. · Nature · 2012 · 1.5K citations · Full text

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World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions

Stephen Kaptoge, Lisa Pennells, Dirk De Bacquer et al. · The Lancet Global Health · 2019 · 1.1K citations · Full text