Concepedia

Synthesis and biological evaluation of <i>S</i>-lipidated lipopeptides of a connexin 43 channel inhibitory peptide

Sung‐Hyun Yang, Connor A. Clemett, Margaret A. Brimble, Simon J. O’Carroll, Paul W. R. Harris

RSC Medicinal Chemistry · 2020 · 10 citations · 37 references

DOIFull text

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Concepts

Abstract

-lipidated Peptide5 analogues containing straight-chain, branched, or aromatic lipids. The modified peptides were assessed for their effect on hemichannel opening and the most promising candidates were evaluated in serum stability studies.

References

37

Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide

Jesper Lau, Paw Bloch, Lauge Schäffer et al. · Journal of Medicinal Chemistry · 2015 · 1K citations · Full text

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Potent Derivatives of Glucagon-like Peptide-1 with Pharmacokinetic Properties Suitable for Once Daily Administration

Lotte Bjerre Knudsen, Per F. Nielsen, Per Olaf Huusfeldt et al. · Journal of Medicinal Chemistry · 2000 · 687 citations · Full text

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The emergence of peptides in the pharmaceutical business: From exploration to exploitation

Thomas Uhlig, Themis Kyprianou, Filippo Martinelli et al. · EuPA Open Proteomics · 2014 · 447 citations · Full text

, , +16

Peptides Containing β-Amino Acid Patterns: Challenges and Successes in Medicinal Chemistry

Chiara Cabrele, Tamás A. Martinek, Oliver Reiser et al. · Journal of Medicinal Chemistry · 2014 · 350 citations · Full text

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Serum Stabilities of Short Tryptophan- and Arginine-Rich Antimicrobial Peptide Analogs

Leonard T. Nguyen, Johnny Chau, Nicole A. Perry et al. · PLoS ONE · 2010 · 332 citations · Full text

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