CD8+CD57+ T cells exhibit distinct features in human non-small cell lung cancer

Abstract

Our data indicate that the failure of the immune system to fight cancer progression could be a result of impaired CD8+ T-cell functional maturation into fully differentiated effector T cells within the tumor microenvironment. Boosting IL-15 activity might promote tumor-reactive CD8+ T-cell functional maturation while preserving their proliferative activity.

References

Page 1

	Year	Citations
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection Shawn D. Blackburn, Haina Shin, W. Nicholas Haining, Nature Immunology Viral PersistenceImmunologyAntiviral ResponseVirologyAutoimmunity	2008	2K
T-cell invigoration to tumour burden ratio associated with anti-PD-1 response Alexander C. Huang, Michael A. Postow, Robert J. Orlowski, Nature Burden RatioCancer ImmunosurveillanceMedicineImmunologyTumor Immunity	2017	1.6K
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin Andrew M. Intlekofer, Naofumi Takemoto, E. John Wherry, Nature Immunology Signal TransductionLymphocyte DevelopmentT-regulatory CellImmunologyAutoimmunity	2005	1.2K
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade Daniela S. Thommen, Viktor H. Koelzer, Petra Herzig, Nature Medicine Cancer ImmunosurveillanceNon-small-cell Lung CancerPd-1 BlockadeMedicineImmunology	2018	1.1K
PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors Alena Gros, Paul F. Robbins, Xin Yao, Journal of Clinical Investigation	2014	1.1K
Control of Effector CD8 <sup>+</sup> T Cell Function by the Transcription Factor <i>Eomesodermin</i> Erika L. Pearce, Alan C. Mullen, Gislâine A. Martins, Science	2003	987
Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1–targeted therapy in lung cancer patients Alice O. Kamphorst, Rathi N. Pillai, Shu Yang, Proceedings of the National Academy of Sciences	2017	847
Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients Alena Gros, Maria R. Parkhurst, Eric Tran, Nature Medicine Skin CancerMalignant Blood DisorderMelanomaHematologyImmunology	2016	825
TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision Zeyu Chen, Zhicheng Ji, Shin Foong Ngiow, Immunity Transcriptional RegulationSignal TransductionT-regulatory CellImmunologyCellular Regulatory Mechanism	2019	663
ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomised, open-label, phase 1b trial John Wrangle, Vamsidhar Velcheti, Manish R. Patel, The Lancet Oncology Il-15 SuperagonistMedicineImmunologyClinical TrialsImmune Checkpoint Inhibitor	2018	410

Page 1