Concepedia

Enzymatic Synthesis of Chondroitin Sulfate E to Attenuate Bacteria Lipopolysaccharide-Induced Organ Damage

Jine Li, Erica Sparkenbaugh, Guowei Su, Fuming Zhang, Yongmei Xu, Ke Xia, Pen He, Sultan Nacak Baytaş, Shannon M. Pechauer, Anand Padmanabhan,

ACS Central Science · 2020 · 34 citations · 39 references

DOIFull text

Open access

Concepts

Abstract

does not display anticoagulant activity nor react with heparin-induced thrombocytopenia antibodies isolated from patients. The successful synthesis of CS-E oligosaccharides provides structurally defined carbohydrates for advancing CS-E research and offers a potential therapeutic agent to treat life-threatening systemic inflammation.

References

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