Concepedia

TOX is expressed by exhausted and polyfunctional human effector memory CD8 <sup>+</sup> T cells

Takuya Sekine, André Perez‐Potti, Son Nguyen, Jean‐Baptiste Gorin, Vincent H. Wu, Emma Gostick, Sian Llewellyn‐Lacey, Quirin Hammer, Sara Falck‐Jones, Sindhu Vangeti,

Science Immunology · 2020 · 238 citations · 50 references

DOI

Concepts

Abstract

The transcription factor TOX is not exclusively linked to T cell exhaustion (see related Focus by Utzschneider and Kallies).

References

50

The single-cell transcriptional landscape of mammalian organogenesis

Junyue Cao, Malte Spielmann, Xiaojie Qiu et al. · Nature · 2019 · 4.8K citations

, , +14

Restoring function in exhausted CD8 T cells during chronic viral infection

Daniel L. Barber, E. John Wherry, David Masopust et al. · Nature · 2005 · 4K citations

, , +14

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

Cheryl L. Day, Daniel E. Kaufmann, Photini Kiepiela et al. · Nature · 2006 · 2.6K citations

, , +17

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

Se Jin Im, Masao Hashimoto, Michael Y. Gerner et al. · Nature · 2016 · 2.1K citations · Full text

, , +16

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

Allan Zajac, Joseph N. Blattman, Kaja Murali‐Krishna et al. · The Journal of Experimental Medicine · 1998 · 2K citations · Full text

, , +17