Concepedia

Design, synthesis and biological evaluation of novel 6-phenyl-1,3a,4,10b-tetrahydro-2H-benzo[c]thiazolo[4,5-e]azepin-2-one derivatives as potential BRD4 inhibitors

Qifei Li, Jieming Li, Yan Cai, Yuxing Zou, Bin Chen, Feng Zou, Jiaxian Mo, Ting Han, Weiwei Guo, Wenlong Huang,

Bioorganic & Medicinal Chemistry · 2020 · 13 citations · 23 references

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References

23

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Jake Delmore, Ghayas C. Issa, Madeleine E. Lemieux et al. · Cell · 2011 · 2.8K citations · Full text

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Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

P. Filippakopoulos, S. Picaud, Maria Mangos et al. · Cell · 2012 · 1.8K citations · Full text

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Structure and ligand of a histone acetyltransferase bromodomain

Christophe Dhalluin, Justin E. Carlson, Lei Zeng et al. · Nature · 1999 · 1.7K citations

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Recruitment of P-TEFb for Stimulation of Transcriptional Elongation by the Bromodomain Protein Brd4

Zhiyuan Yang, Jasper H. N. Yik, Ruichuan Chen et al. · Molecular Cell · 2005 · 1.1K citations · Full text

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Brd4 Marks Select Genes on Mitotic Chromatin and Directs Postmitotic Transcription

Anup Dey, Akira Nishiyama, Tatiana Karpova et al. · Molecular Biology of the Cell · 2009 · 326 citations · Full text

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