Concepedia

Alterations in driver genes are predictive of survival in patients with resected pancreatic ductal adenocarcinoma

Caitlin A. McIntyre, Sharon Lawrence, Allison L. Richards, Joanne F. Chou, Winston Wong, Marinela Capanu, Michael F. Berger, Mark T.A. Donoghue, Kenneth H. Yu, Anna M. Varghese,

Cancer · 2020 · 74 citations · 37 references

DOIFull text

Open access

Abstract

In patients with resected PDAC, genomic alterations in KRAS and TP53 are associated with worse outcomes, whereas alterations in HRD genes are associated with a favorable prognosis. Further studies are needed to better define these alterations as biomarkers in resected PDAC.

References

37

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

Lola Rahib, Benjamin D. Smith, Rhonda Aizenberg et al. · Cancer Research · 2014 · 7.1K citations

, , +22

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

Siân Jones, D. Williams Parsons, Jimmy Lin et al. · Science · 2008 · 4K citations · Full text

, , +17

Genomic analyses identify molecular subtypes of pancreatic cancer

Peter J. Bailey, David K. Chang, Kátia Nones et al. · Nature · 2016 · 3.6K citations

, , +3

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

Ahmet Zehir, Ryma Benayed, Ronak Shah et al. · Nature Medicine · 2017 · 3.4K citations · Full text

, , +12

OncoKB: A Precision Oncology Knowledge Base

Debyani Chakravarty, Jianjiong Gao, Sarah Phillips et al. · JCO Precision Oncology · 2017 · 2.6K citations