Polymorphism analysis of the Gly972Arg IRS-1 and Gly1057Asp IRS-2 genes in obese pregnant women

Disruption of IRS-2 causes type 2 diabetes in mice

Dominic J. Withers, Julio Sanchez Gutierrez, Heather Towery et al. · Nature · 1998 · 1.8K citations

Life Sciences, Endocrinology, Molecular Biology +12

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

Eiichi Araki, Myra A. Lipes, Mary‐Elizabeth Patti et al. · Nature · 1994 · 1.3K citations

Life Sciences, Endocrinology, Molecular Biology +17

Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling

Dominic J. Withers, Deborah J. Burks, Heather Towery et al. · Nature Genetics · 1999 · 527 citations

Life Sciences, Endocrinology, Molecular Biology +12

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2

Yoshiaki Kido, Deborah J. Burks, Dominic J. Withers et al. · Journal of Clinical Investigation · 2000 · 496 citations · Full text

Medicine, Endocrinology, Molecular Genetics +17

Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus

Katrine Almind, Henrik Vestergaard, Torben Hansen et al. · The Lancet · 1993 · 331 citations

Medicine, Genetics, Molecular Genetics +12