Concepedia

New Broad-Spectrum Antibiotics Containing a Pyrrolobenzodiazepine Ring with Activity against Multidrug-Resistant Gram-Negative Bacteria

Pietro Picconi, Charlotte K. Hind, Kazi S. Nahar, Shirin Jamshidi, Lucia Di Maggio, Naima Saeed, Bonnie Evans, Jessica Solomons, Matthew E. Wand, J. Mark Sutton,

Journal of Medicinal Chemistry · 2020 · 23 citations · 25 references

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Concepts

Abstract

of 3.16 ± 1.36 mg/L. This study provides a new chemical scaffold for developing novel broad-spectrum antibiotics which can help replenish the pipeline of antibiotics.

References

25

Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances

Irith Wiegand, Kai Hilpert, Robert E. W. Hancock · Nature Protocols · 2008 · 6.1K citations

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The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update

Enis Afgan, Dannon Baker, Bérénice Batut et al. · Nucleic Acids Research · 2018 · 3.9K citations · Full text

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Comprehensive transposon mutant library of <i>Pseudomonas aeruginosa</i>

Michael A. Jacobs, Ashley Alwood, Iyarit Thaipisuttikul et al. · Proceedings of the National Academy of Sciences · 2003 · 1.1K citations · Full text

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A comprehensive library of fluorescent transcriptional reporters for Escherichia coli

Alon Zaslaver, Anat Bren, Michal Ronen et al. · Nature Methods · 2006 · 813 citations

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The Efflux Inhibitor Phenylalanine-Arginine Beta-Naphthylamide (PAβN) Permeabilizes the Outer Membrane of Gram-Negative Bacteria

Ryan P. Lamers, Joseph F. Cavallari, Lori L. Burrows · PLoS ONE · 2013 · 275 citations · Full text

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