A novel pectin from Polygala tenuifolia blocks Aβ42 aggregation and production by enhancing insulin-degradation enzyme and neprilysin

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Colin L. Masters, G. Simms, Nicola A. Weinman et al. · Proceedings of the National Academy of Sciences · 1985 · 4.4K citations · Full text

Life Sciences, Biochemistry, Neurology +17

Oligomeric and Fibrillar Species of Amyloid-β Peptides Differentially Affect Neuronal Viability

Karie N. Dahlgren, Arlene M. Manelli, W. Blaine Stine et al. · Journal of Biological Chemistry · 2002 · 1.4K citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways

Gal Bitan, Marina Kirkitadze, Aleksey Lomakin et al. · Proceedings of the National Academy of Sciences · 2002 · 1.3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Decreased nuclear β‐catenin, tau hyperphosphorylation and neurodegeneration in GSK‐3β conditional transgenic mice

José J. Lucas · The EMBO Journal · 2001 · 898 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +13

Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death

Malcolm A. Leissring, Wesley Farris, Alice Y. Chang et al. · Neuron · 2003 · 708 citations · Full text

Life Sciences, Biochemistry, Neuroscience +16