Concepedia

Gene editing to induce FOXP3 expression in human CD4 <sup>+</sup> T cells leads to a stable regulatory phenotype and function

Yuchi Honaker, Nicholas Hubbard, Yufei Xiang, Logan Fisher, David Hagin, Karen Sommer, Yumei Song, Soo Jung Yang, Christina Lopez, Tori Tappen,

Science Translational Medicine · 2020 · 117 citations · 65 references

DOI

Concepts

Abstract

Gene editing to insert a strong promoter upstream of endogenous FOXP3 conferred T reg -like properties and functions to primary human CD4 + T cells.

References

65

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love, Wolfgang Huber, Simon Anders · Genome biology · 2014 · 100.5K citations · Full text

, , +15

HTSeq—a Python framework to work with high-throughput sequencing data

Simon Anders, Paul Theodor Pyl, Wolfgang Huber · Bioinformatics · 2014 · 22.7K citations · Full text

, , +11

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

Daehwan Kim, Geo Pertea, Cole Trapnell et al. · Genome biology · 2013 · 13.7K citations · Full text

, , +14

Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>

Shohei Hori, Takashi Nomura, Shimon Sakaguchi · Science · 2003 · 8.1K citations

, , +17

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Jason D. Fontenot, Marc A. Gavin, Alexander Y. Rudensky · Nature Immunology · 2003 · 7.7K citations

, , +14