Concepedia

High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade

Kobe Yuen, Lifen Liu, Vinita Gupta, Shravan Madireddi, Shilpa Keerthivasan, Congfen Li, Deepali Rishipathak, Patrick Williams, Edward E. Kadel, Hartmut Koeppen,

Nature Medicine · 2020 · 439 citations · 27 references

Open access

Concepts

Life SciencesImmunologyOncologyCancer ImmunologyImmunotherapyTumor ImmunologyAntitumor T Cell ResponsesCancer ImmunotherapyCheckpoint Inhibitor TherapyImmune Checkpoint InhibitorsImmuno-oncology BiomarkersTumor-associated AntigensCancer-associated ImmunosuppressionCd8 Positive T Cell ResponsesCd8+ Tumor-infiltrating LymphocytesPd-l1 BlockadeProgrammed Cell Death Protein 1 (Pd-1) PathwayProgrammed Death-ligand 1 InhibitionProgrammed Death-ligand 1 Targeting

References

27

Comprehensive Integration of Single-Cell Data

Tim Stuart, Andrew Butler, Paul Hoffman et al. · Cell · 2019 · 16.9K citations · Full text

Life Sciences, Bioinformatics, Cell Biology +14

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

Peng Jiang, Shengqing Gu, Deng Pan et al. · Nature Medicine · 2018 · 5.6K citations · Full text

Life Sciences, Immunology, Oncology +14

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Sanjeev Mariathasan, Shannon J. Turley, Dorothee Nickles et al. · Nature · 2018 · 5.5K citations

Life Sciences, Immunology, Oncology +16

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

Dvir Aran, Agnieszka Looney, Leqian Liu et al. · Nature Immunology · 2019 · 5.3K citations

Life Sciences, Cell Biology, Immunology +10

Software for Computing and Annotating Genomic Ranges

Michael Lawrence, Wolfgang Huber, Hervé Pagès et al. · PLoS Computational Biology · 2013 · 5K citations · Full text

Life Sciences, Bioinformatics, Genetics +16