CD4⁺ T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion

Abstract

These results indicate that age-related CD4⁺ T cells, especially Th17 cells-secreted factors have the potential to contribute to prostate carcinogenesis. Our work could prompt further research using autochthonous PCa mouse models at different ages to elucidate the functional role of Th17 response in prostate carcinogenesis during aging.