Concepedia

Epigenetic mechanisms and metabolic reprogramming in fibrogenesis: dual targeting of G9a and DNMT1 for the inhibition of liver fibrosis

Marina Bárcena‐Varela, Hannah L. Paish, Laura Álvarez, Iker Uriarte, María U. Latasa, Eva Santamaría, Miriam Recalde, Maria Rosa Garate, Alex Clavería-Cabello, Leticia Colyn,

Gut · 2020 · 85 citations · 37 references

DOI

Abstract

Dual G9a/DNMT1 inhibition by compounds like CM272 may be a novel therapeutic strategy for treating liver fibrosis.

References

37

TLR4 enhances TGF-β signaling and hepatic fibrosis

Ekihiro Seki, Samuele De Minicis, Christoph H. Österreicher et al. · Nature Medicine · 2007 · 1.9K citations

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Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis

Liang‐Guo Xu · Gut · 2004 · 1K citations · Full text

Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer

Chenfang Dong, Tingting Yuan, Yadi Wu et al. · Cancer Cell · 2013 · 814 citations · Full text

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Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

Tatiana Kisseleva, Min Cong, Yong‐Han Paik et al. · Proceedings of the National Academy of Sciences · 2012 · 777 citations

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A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

Michael E. Pacold, Kyle R. Brimacombe, Sze Ham Chan et al. · Nature Chemical Biology · 2016 · 571 citations · Full text

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