Epigenetic mechanisms and metabolic reprogramming in fibrogenesis: dual targeting of G9a and DNMT1 for the inhibition of liver fibrosis - Concepedia

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Epigenetic mechanisms and metabolic reprogramming in fibrogenesis: dual targeting of G9a and DNMT1 for the inhibition of liver fibrosis

85

Citations

37

References

2020

Year

Marina Bárcena‐Varela, Hannah L. Paish, Laura Álvarez, Iker Uriarte, María U. Latasa, Eva Santamaría, Miriam Recalde, Maria Rosa Garate, Alex Clavería-Cabello, Leticia Colyn,

Abstract

Dual G9a/DNMT1 inhibition by compounds like CM272 may be a novel therapeutic strategy for treating liver fibrosis.

References

	Year	Citations
TLR4 enhances TGF-β signaling and hepatic fibrosis Ekihiro Seki, Samuele De Minicis, Christoph H. Österreicher, Nature Medicine InflammationFibrosisHepatologyLiver PhysiologyTgf-β Signaling	2007	1.9K
Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis Liang‐Guo Xu Gut	2004	1K
Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer Chenfang Dong, Tingting Yuan, Yadi Wu, Cancer Cell Signaling PathwayCell RegulationMedicineCancer Cell BiologyBreast Cancer	2013	814
Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis Tatiana Kisseleva, Min Cong, Yong‐Han Paik, Proceedings of the National Academy of Sciences Liver FibrosisPathologyCholangiopathiesCirrhosisHepatotoxicity	2012	777
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate Michael E. Pacold, Kyle R. Brimacombe, Sze Ham Chan, Nature Chemical Biology Molecular PharmacologyMedicinal ChemistrySerine SynthesisPharmaceutical ChemistryBiochemistry	2016	571
Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis Na Xie, Zheng Tan, Sami Banerjee, American Journal of Respiratory and Critical Care Medicine	2015	560
Fructose-1,6-bisphosphatase opposes renal carcinoma progression Bo Li, Bo Qiu, David S.M. Lee, Nature Tumor BiologyUrologyGenitourinary CancerKidney ResearchRenal Pathology	2014	527
Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice Juliane S. Troeger, Ingmar Mederacke, Geum‐Youn Gwak, Gastroenterology Liver FibrosisHepatic Stellate CellsPathologyFatty Liver DiseaseCholangiopathies	2012	501
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation Jiangbin Ye, Anthony Mancuso, Xuemei Tong, Proceedings of the National Academy of Sciences Serine SynthesisMtorc1 ActivityMetabolic RemodelingCancer BiologyTumor Biology	2012	419
G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription Makoto Tachibana, Yasuko Matsumura, Mikiko Fukuda, The EMBO Journal ChromatinTranscriptional RegulationNatural SciencesGeneticsDna Methylation	2008	405

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