Concepedia

Are There Any Experimental Perfusion Data that Preferentially Support the Dispersion and Parallel-Tube Models over the Well-Stirred Model of Organ Elimination?

Jasleen K. Sodhi, Hong-Jaan Wang, Leslie Z. Benet

Drug Metabolism and Disposition · 2020 · 38 citations · 24 references

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Concepts

References

24

On the Uptake of Materials by the Intact Liver. THE TRANSPORT AND NET REMOVAL OF GALACTOSE

Carl A. Goresky, Glen G. Bach, B. Nadeau · Journal of Clinical Investigation · 1973 · 299 citations · Full text

, , +14

Influence of Route of Administration on Drug Availability

Malcolm Rowland · Journal of Pharmaceutical Sciences · 1972 · 265 citations

, , +12

Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation

K. Sandy Pang, Malcolm Rowland · Journal of Pharmacokinetics and Biopharmaceutics · 1977 · 214 citations

, , +16

Prediction of Human Metabolic Clearance from In Vitro Systems: Retrospective Analysis and Prospective View

David Hallifax, Joanne Foster, J. Brian Houston · Pharmaceutical Research · 2010 · 195 citations

, , +12

Clearance Prediction Methodology Needs Fundamental Improvement: Trends Common to Rat and Human Hepatocytes/Microsomes and Implications for Experimental Methodology

Francesca Wood, J. Brian Houston, David Hallifax · Drug Metabolism and Disposition · 2017 · 153 citations · Full text

, , +17