Journal of Ethnopharmacology · 2020 · 64 citations · 21 references
Life SciencesImmunologyPharmacologyCell SignalingInflammationInnate ImmunityBioactive Food ComponentsInflammatory Cell ResponsesInflammatory Cell SignalingInflammatory SignalingMacrophage BiologyOxidative Stress In InflammationAnti-inflammatory Natural ProductsMacrophage ImmunomodulationMacrophage Inflammatory ResponsesMacrophage Oxidative StressMacrophage Reactive Oxygen Species ResponsesMacrophage Signaling PathwaysNrf2 Pathway ActivationNrf2 Signaling Pathway
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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag et al. · Nature · 2018 · 1.8K citations