Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

Fuqin Fan, Zhixiang He, Lulu Kong, +24

Science Translational Medicine

Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity

Jing Geng, Xiufeng Sun, Ping Wang, +22

Nature Immunology

InflammationHost ResponseMicrobial PathogensMedicineBactericidal Activity +11

Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis

Ping Wang, Jing Geng, Jiahui Gao, +17

Nature Communications

TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection

Jing Geng, Yiran Shi, Jinjia Zhang, +13

Nature Communications

Microbial PathogensInnate Immune SystemImmunologyInnate ImmunityImmune System +19

The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells

Jing Geng, Shujuan Yu, Hao Zhao, +15

Nature Immunology

Transcriptional RegulationDevelopmental BiologyCell RegulationT-regulatory CellGene Regulation +9

Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2

Shihao Zhang, Qinghua Chen, Qingxu Liu, +21

Cancer Cell

Signal TransductionSignaling PathwayTumor SuppressorMedicineCell Biology +2

Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis

Hongtan Wu, Luyao Wei, Fuqin Fan, +22

Nature Communications

Cell DeathEr StressCancer BiologyTumor BiologySignaling Pathway +21

The Ets Transcription Factor GABP Is a Component of the Hippo Pathway Essential for Growth and Antioxidant Defense

Hongtan Wu, Yubo Xiao, Shihao Zhang, +20

Cell Reports

FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis

Suyuan Ji, Qingxu Liu, Shihao Zhang, +24

Developmental Cell

Fgf15 Activates HippoSignaling PathwayHepatologyLiver TumorigenesisBiliary Cancer +9

THZ1 reveals CDK7-dependent transcriptional addictions in pancreatic cancer

Ping Lu, Jing Geng, Lei Zhang, +10

Oncogene

Pancreatic CancerMedicineCancer BiologyCell BiologyCell Signaling +1