VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-<i>κ</i>B Pathways to Improve Functional Outcomes in TBI Mice - Concepedia

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VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-<i>κ</i>B Pathways to Improve Functional Outcomes in TBI Mice

DOI Full Paper Access

104

Citations

58

References

2020

Year

Zhezhe Sun, Mark Nyanzu, Su Yang, Xiaohong Zhu, Kankai Wang, Junnan Ru, Enxing Yu, Hengli Zhang, Zhenzhong Wang, Jie Shen,

Oxidative Medicine and Cellular Longevity

Abstract

In conclusion, VX765 can counteract neurological damage after TBI by reducing pyroptosis and HMGB1/TLR4/NF-<i>κ</i>B pathway activities. VX765 may have a good therapeutic effect on TBI.

References

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