Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Yupeng Wang, Wenqing Gao, Xuyan Shi, +5

Nature

MedicineApoptosisPyroptosisChemotherapy DrugsCell Death +7

Pore-forming activity and structural autoinhibition of the gasdermin family

Jingjin Ding, Kun Wang, Wang Liu, +6

Nature

Gasdermin FamilyProtein SecretionBiochemistryGasderminsCarbohydrate-protein Interaction

Inflammatory caspases are innate immune receptors for intracellular LPS

Jianjin Shi, Yue Zhao, Yupeng Wang, +5

Nature

InflammationToll-like ReceptorsAutoimmune DiseaseInnate Immune SystemImmunology +5

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

Zhiwei Zhou, Huabin He, Kun Wang, +12

Science

A bioorthogonal system reveals antitumour immune function of pyroptosis

Qinyang Wang, Yupeng Wang, Jingjin Ding, +6

Nature

Bioorthogonal System RevealsApoptosisImmunologyTumor SuppressorMedicine +1

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

Kun Wang, Qi Sun, Xiu Zhong, +8

Cell

Gsdmd TargetingSignal TransductionProtein FunctionBiochemistryG Protein-coupled Receptor +10

A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy

Yue Xu, Ping‐Kun Zhou, Sen Cheng, +13

Cell

Cell AutophagyMitophagySignal TransductionPathogenesisAutophagy +5

Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose

Ping‐Kun Zhou, Yang She, Na Dong, +14

Nature

Host ResponseSignal TransductionPathogenesisImmunologyInnate Immune System +8

Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11

Zilin Li, Wang Liu, Jiaqi Fu, +10

Nature

BiochemistryNatural SciencesProtein BiosynthesisApoptosisCell Death +5

Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome

Xuyan Shi, Qichao Sun, Yanjie Hou, +5

Nature

InflammationMedicineImmunologyAutoimmunityInflammasome +4