HotSpot3D web server: an integrated resource for mutation analysis in protein 3D structures

Abstract

MOTIVATION: HotSpot3D is a widely used software for identifying mutation hotspots on the 3D structures of proteins. To further assist users, we developed a new HotSpot3D web server to make this software more versatile, convenient and interactive. RESULTS: The HotSpot3D web server performs data pre-processing, clustering, visualization and log-viewing on one stop. Users can interactively explore each cluster and easily re-visualize the mutational clusters within browsers. We also provide a database that allows users to search and visualize proximal mutations from 33 cancers in the Cancer Genome Atlas. AVAILABILITY AND IMPLEMENTATION: http://niulab.scgrid.cn/HotSpot3D/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.