Concepedia

Mutational Hotspots

Mutational Hotspots is a genomic phenomenon characterized by specific regions within a viral genome that exhibit significantly elevated rates of mutation compared to surrounding sequences, often due to intrinsic structural or enzymatic biases in replication or repair mechanisms.

407

Publications

29.6K

Citations

3.1K

Authors

1.1K

Institutions

Publications per year

2017–2026

141

Parents

Publications

407

Preferential Formation of Benzo[ <i>a</i> ]pyrene Adducts at Lung Cancer Mutational Hotspots in <i>P53</i>

Mikhail F. Denissenko, Annie Pao, Moon‐shong Tang et al. · Science · 1996 · 1.7K citations

, , +17

Gain of Function of a p53 Hot Spot Mutation in a Mouse Model of Li-Fraumeni Syndrome

Gene A. Lang, Tomoo Iwakuma, Young‐Ah Suh et al. · Cell · 2004 · 1.1K citations · Full text

, , +15

The Accuracy of Reverse Transcriptase from HIV-1

John D. Roberts, Katarzyna Bębenek, Thomas A. Kunkel · Science · 1988 · 980 citations

, , +17

<i>APC</i> mutations in sporadic colorectal tumors: A mutational “hotspot” and interdependence of the “two hits”

Andrew Rowan, H. Lamlum, Mohammad Ilyas et al. · Proceedings of the National Academy of Sciences · 2000 · 505 citations

, , +17

AID Mediates Hypermutation by Deaminating Single Stranded DNA

Sarah K. Dickerson, Eleonora Market, Eva Besmer et al. · The Journal of Experimental Medicine · 2003 · 459 citations · Full text

, , +17

1–5 of 407

Authors

3.1K

  1. JU
    Jouni Uitto

    Thomas Jefferson University, United States

    4 publications · 158 citations

    4

    h-index

  2. GM
    Gennady M. Verkhivker

    Chapman University, United States

    4 publications · 148 citations

    4

    h-index

  3. JA
    John A. McGrath

    St Thomas' Hospital, United Kingdom

    4 publications · 189 citations

    4

    h-index

  4. MS
    Matthias Schlesner

    German Cancer Research Center, Germany

    4 publications · 319 citations

    4

    h-index

  5. ST
    Susan T. Lovett

    Brandeis University, United States

    4 publications · 207 citations

    4

    h-index

1–5 of 3.1K

Institutions

1.1K

  1. Inserm

    Paris, France

    18 h-index

    129 publications

    8.6K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    14 h-index

    58 publications

    3.2K citations

  3. Harvard University

    Cambridge, United States

    13 h-index

    49 publications

    3.7K citations

  4. The University of Texas MD Anderson Cancer Center

    Houston, United States

    12 h-index

    75 publications

    23.6K citations

  5. University of Oxford

    Oxford, United Kingdom

    11 h-index

    25 publications

    1.5K citations

  6. Heidelberg University

    Heidelberg, Germany

    10 h-index

    115 publications

    9.1K citations

  7. Assistance Publique – Hôpitaux de Paris

    Paris, France

    10 h-index

    66 publications

    3.9K citations

  8. German Cancer Research Center

    Heidelberg, Germany

    10 h-index

    89 publications

    6.7K citations

1–8 of 1.1K

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 14 publications · 1.8K citations

    14

    h-index

  2. Human Mutation

    15 publications · 772 citations

    14

    h-index

  3. PubMed

    Repository · 12 publications · 1K citations

    12

    h-index

  4. PLoS ONE

    11 publications · 570 citations

    11

    h-index

  5. Carcinogenesis

    11 publications · 1.4K citations

    10

    h-index

1–5