Concepedia

Publication | Open Access

m6A-dependent glycolysis enhances colorectal cancer progression

DOIFull Paper Access

440

Citations

43

References

2020

Year

Chaoqin Shen, Baoqin Xuan, Tingting Yan, Yanru Ma, Pingping Xu, Xianglong Tian, Xinyu Zhang, Yingying Cao, Dan Ma, Xiaoqiang Zhu,
Molecular Cancer

Abstract

METTL3 is a functional and clinical oncogene in CRC. METTL3 stabilizes HK2 and SLC2A1 (GLUT1) expression in CRC through an m<sup>6</sup>A-IGF2BP2/3- dependent mechanism. Targeting METTL3 and its pathway offer alternative rational therapeutic targets in CRC patients with high glucose metabolism.

References

YearCitations

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