Science Immunology · 2020 · 31 citations · 26 references
Life SciencesGeneticsMolecular BiologyComparative ImmunologyImmunogeneticsMolecular EvolutionAntigen Receptor Gene RearrangementB Cell DevelopmentEvolution Of Immune GenesHumoral Immune ResponsesImmune Repertoire FormationImmunoglobulin DiversityActivation-induced Cytidine DeaminaseAntigen Receptor DiversificationAntigen Receptor Gene LociB Lymphocyte DevelopmentGene AssemblyImmunoglobulin Gene DiversificationSomatic Diversification MechanismsSomatic Diversification Of Antibodies
antibody genes. CDA2 is closely related to activation-induced cytidine deaminase (AID), which is essential for the elaboration of immunoglobulin gene repertoires in jawed vertebrates. Our results thus identify a convergent mechanism of antigen receptor gene assembly and diversification that independently evolved in the two sister branches of vertebrates.
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Efficient genome editing in zebrafish using a CRISPR-Cas system
Woong Y. Hwang, Yanfang Fu, Deepak Reyon et al. · Nature Biotechnology · 2013 · 3K citations · Full text
A hyperconversion mechanism generates the chicken light chain preimmune repertoire
Claude–Agnès Reynaud, Viviane Anquez, Hélène Grimal et al. · Cell · 1987 · 686 citations
Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey
Zeev Pancer, Chris T. Amemiya, Götz R. A. Ehrhardt et al. · Nature · 2004 · 659 citations · Full text