Concepedia

Interferon Regulatory Factor‐5 in Resident Macrophage Promotes Polycystic Kidney Disease

Kurt A. Zimmerman, Jifeng Huang, Lan He, Dustin Z. Revell, Zhang Li, Jung-Shan Hsu, Wayne R. Fitzgibbon, E. Starr Hazard, Gary Hardiman, Michal Mrug,

Kidney360 · 2020 · 28 citations · 44 references

DOIFull text

Open access

Abstract

These data suggest that <i>Irf5</i> promotes inflammatory cytokine production in resident macrophages resulting in accelerated cystogenesis.

References

44

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

Christian Schulz, Elisa Gomez Perdiguero, Laurent Chorro et al. · Science · 2012 · 2.5K citations

Efficient Recombination in Diverse Tissues by a Tamoxifen-Inducible Form of Cre: A Tool for Temporally Regulated Gene Activation/Inactivation in the Mouse

Shigemi Hayashi, Andrew P. McMahon · Developmental Biology · 2002 · 1.4K citations

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IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

Thomas Krausgruber, Katrina Blazek, Tim Smallie et al. · Nature Immunology · 2011 · 1.3K citations · Full text

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

Akinori Takaoka, Hideyuki Yanai, Seiji Kondo et al. · Nature · 2005 · 1K citations

, , +11

Treatment of Persistent Gross Hematuria with Tranexamic Acid in Autosomal Dominant Polycystic Kidney Disease

Qing Yao, Ming Wu, Jie Zhou et al. · Kidney & Blood Pressure Research · 2017 · 846 citations · Full text