Background: Growth monitoring and promotion (GMP) activities serve as an important platform for the implementation of child survival interventions to reduce malnutrition, infectious diseases and death among children. In recent times, there has been a steady decline in GMP outcome indicators in the Lawra district. The appropriate practices of GMP help in improving knowledge, attitudes and practices of caregivers towards child nutrition and health. Therefore, this study seeks to assess knowledge, attitude and practices of growth monitoring and promotion and associated factors among caregivers. Methods: A descriptive cross-sectional study design was used to study 300 caregivers’. Multi-stage sampling technique was used to select the participants. A semi-structured questionnaire applying face to face interview approach was used to collect data from participants. Descriptive statistics and associations between dependent and independent variables were done using Pearson chi-square and logistic regression analysis. Results: The results indicated 53% of the caregivers’ with good (high) knowledge in Growth Monitoring and Promotion (GMP) activities, 98% with good (high) attitudes towards GMP activities and 70% with good (high) practices in GMP. Also, 16.2% of caregivers’ children had faltered in growth. Occupation was associated with knowledge (p=.013), and attitude (p=.014). Again, educational status (p=.026) was associated with knowledge in GMP, marital status (p=.009) and child relation with caregiver (p=.021) were associated with attitude in GMP. Also tribe (p=.019) and child relation with caregiver (p=.019) were significantly associated with practices in GMP. Conclusions: Notwithstanding the achievement in the coverage of GMP, implementation of Infant and Young Child Feeding (IYCF) program and Information, Education and Communication (IE&C) activities in district, the findings on GMP outcome (knowledge and practice) is not satisfactorily. District Health Directorate need to intensify and strengthen IYCF activities, home visits, health education, and growth monitoring and promotion services.

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