bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 188 citations · 13 references
Life SciencesImmunologyInfectious DiseasesMolecular VirologyVaccinologyVirologyAntibody DiscoveryAntibody-antigen RecognitionAntiviral TherapyMonoclonal Antibody TherapyTherapeutic Antibody DevelopmentViral VaccinesAntibodiesAntibody-mediated Viral NeutralizationAntiviral TreatmentCoronavirus VaccinesHuman Health EffectsIdentityTreatment Of Coronavirus InfectionsViral Spike Proteins
The 2019 novel coronavirus has caused thousands of infections and deaths worldwide, and no specific antiviral treatment or vaccine is yet available. The study aimed to evaluate whether SARS‑CoV–specific antibodies cross‑react with the 2019‑nCoV spike protein, to inform rapid vaccine and therapeutic antibody development. CR3022 binds the 2019‑nCoV RBD with high affinity (KD = 6.3 nM) at a non‑ACE2 epitope, suggesting it could serve as a therapeutic candidate, whereas other potent SARS‑CoV antibodies that target the ACE2 site do not bind, highlighting the need for new monoclonal antibodies.
The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 11,900 laboratory-confirmed human infections, including 259 deaths, posing a serious threat to human health. Currently, however, there is no specific antiviral treatment or vaccine. Considering the relatively high identity of receptor-binding domain (RBD) in 2019-nCoV and SARS-CoV, it is urgent to assess the cross-reactivity of anti-SARS CoV antibodies with 2019-nCoV spike protein, which could have important implications for rapid development of vaccines and therapeutic antibodies against 2019-nCoV. Here, we report for the first time that a SARS-CoV-specific human monoclonal antibody, CR3022, could bind potently with 2019-nCoV RBD (KD of 6.3 nM). The epitope of CR3022 does not overlap with the ACE2 binding site within 2019-nCoV RBD. These results suggest that CR3022 may have the potential to be developed as candidate therapeutics, alone or in combination with other neutralizing antibodies, for the prevention and treatment of 2019-nCoV infections. Interestingly, some of the most potent SARS-CoV-specific neutralizing antibodies (e.g. m396, CR3014) that target the ACE2 binding site of SARS-CoV failed to bind 2019-nCoV spike protein, implying that the difference in the RBD of SARS-CoV and 2019-nCoV has a critical impact for the cross-reactivity of neutralizing antibodies, and that it is still necessary to develop novel monoclonal antibodies that could bind specifically to 2019-nCoV RBD.
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Structure of SARS Coronavirus Spike Receptor-Binding Domain Complexed with Receptor
Fang Li, Wenhui Li, Michael Farzan et al. · Science · 2005 · 2.2K citations