Concepedia

Publication | Open Access

Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants

DOIFull Paper Access

737

Citations

46

References

2006

Year

Jan ter Meulen, Edward N. van den Brink, Leo L. M. Poon, Wilfred E. Marissen, Cynthia Sau-Wai Leung, Freek Cox, Chung Yan Cheung, Arjen Q. Bakker, Johannes A. Bogaards, Els van Deventer,
PLoS Medicine

Abstract

The combination of two noncompeting human mAbs CR3014 and CR3022 potentially controls immune escape and extends the breadth of protection. At the same time, synergy between CR3014 and CR3022 may allow for a lower total antibody dose to be administered for passive immune prophylaxis of SARS-CoV infection.

References

YearCitations

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