Concepedia

Alteration of fatty acid oxidation by increased CPT1A on replicative senescence of placenta-derived mesenchymal stem cells

Jin Seok, Hyun Sook Jung, Sohae Park, Jung Ok Lee, Chong Jai Kim, Gi Jin Kim

Stem Cell Research & Therapy · 2020 · 234 citations · 23 references

DOIFull text

Open access

Abstract

These findings suggest that alteration of FAO by increased CPT1A plays an important role in mitochondrial dysfunction and senescence of PD-MSCs during long-term cultivation.

References

23

The serial cultivation of human diploid cell strains

Leonard Hayflick, Paul S. Moorhead · Experimental Cell Research · 1961 · 8.3K citations

, , +5

Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC

Ralf Hass, Cornelia Kasper, Stefanie Böhm et al. · Cell Communication and Signaling · 2011 · 1.7K citations · Full text

Adiponectin Increases Fatty Acid Oxidation in Skeletal Muscle Cells by Sequential Activation of AMP-Activated Protein Kinase, p38 Mitogen-Activated Protein Kinase, and Peroxisome Proliferator–Activated Receptor α

Myeong Jin Yoon, Gha Young Lee, Jun-Jae Chung et al. · Diabetes · 2006 · 530 citations · Full text

Metabolic Inflexibility: When Mitochondrial Indecision Leads to Metabolic Gridlock

Deborah M. Muoio · Cell · 2014 · 404 citations · Full text

, , +8

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

Olga Moiseeva, Véronique Bourdeau, Antoine E. Roux et al. · Molecular and Cellular Biology · 2009 · 386 citations · Full text

, , +11