Concepedia

Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice

Marcelo Borges Cavalcante, Tatiana D. Saccon, Allancer Nunes, James L. Kirkland, Tamar Tchkonia, Augusto Schneider, Michał M. Masternak

Aging · 2020 · 79 citations · 39 references

DOIFull text

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Concepts

Abstract

signaling pathway in uterine aging and suggest for the first time a possible anti-fibrotic effect in the uterus of D+Q senolytic therapy.

References

39

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Yi Zhu, Tamar Tchkonia, Tamar Pirtskhalava et al. · Aging Cell · 2015 · 2.4K citations · Full text

, , +17

Senolytics improve physical function and increase lifespan in old age

Ming Xu, Tamar Pirtskhalava, Joshua N. Farr et al. · Nature Medicine · 2018 · 2.2K citations

, , +14

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

LaTonya J. Hickson, Larissa Prata, Shane A. Bobart et al. · EBioMedicine · 2019 · 1.3K citations · Full text

, , +17

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

Jamie N. Justice, Anoop M. Nambiar, Tamar Tchkonia et al. · EBioMedicine · 2019 · 1.2K citations · Full text

, , +15

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

Carolyn M Roos, Bin Zhang, Allyson K. Palmer et al. · Aging Cell · 2016 · 723 citations · Full text

, , +17