Concepedia

Design, synthesis and anti-Alzheimer's disease activity study of xanthone derivatives based on multi-target strategy

Xiaodi Kou, Lulu Song, Yunhua Wang, Yu Qiao, Hui Ju, Ai‐Hong Yang, Rui Shen

Bioorganic & Medicinal Chemistry Letters · 2019 · 57 citations · 22 references

Open access

Concepts

PharmacyMedicinal ChemistryPharmacologyDrug DesignDrug DiscoveryStructure-activity RelationshipsHit-to-lead OptimizationLead Compound DesignLead DiscoveryLigand-based DesignMulti-target Drug DesignPotency OptimizationChemical Synthesis Of AnaloguesCovalent Hit-to-lead OptimizationDementia Drug DevelopmentHit-to-lead Library ExpansionLigand-based Multi-target DesignMedicinal Chemistry ApplicationsMulti-target Selectivity

References

22

A new and rapid colorimetric determination of acetylcholinesterase activity

George L. Ellman, K. Diane Courtney, Valentino Andres et al. · Biochemical Pharmacology · 1961 · 26.9K citations

Life Sciences, Biochemistry, Pharmacology +14

2016 Alzheimer's disease facts and figures

Alzheimer s & Dementia · 2016 · 5.1K citations

Medicine, Geriatric Medicine, Population Health Sciences +17

2018 Alzheimer's disease facts and figures

Alzheimer s & Dementia · 2018 · 1.9K citations

Medicine, Geriatric Medicine, Neurology +17

Superoxide‐dependent formation of hydroxyl radicals in the presence of iron chelates

Barry Halliwell · FEBS Letters · 1978 · 743 citations

Life Sciences, Biochemistry, Chemistry +15

Resolving controversies on the path to Alzheimer's therapeutics

Dennis J. Selkoe · Nature Medicine · 2011 · 494 citations

Medicine, Neurology, Neuroscience +10