Berberine suppresses colon cancer cell proliferation by inhibiting the SCAP/SREBP-1 signaling pathway-mediated lipogenesis

Cholesterol and 25-Hydroxycholesterol Inhibit Activation of SREBPs by Different Mechanisms, Both Involving SCAP and Insigs

Christopher M. Adams, Julian Reitz, Jef K. De Brabander et al. · Journal of Biological Chemistry · 2004 · 454 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

EGFR Signaling Through an Akt-SREBP-1–Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

Deliang Guo, Robert M. Prins, Julie Dang et al. · Science Signaling · 2009 · 344 citations · Full text

Life Sciences, Cell Biology, Pharmacology +9

Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers

Tore Skotland, Kim Ekroos, Dimple Kauhanen et al. · European Journal of Cancer · 2016 · 340 citations

Medicine, Molecular Biology, Urology +16

Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth

Chunming Cheng, Peng Ru, Feng Geng et al. · Cancer Cell · 2015 · 330 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins

Li-Ping Sun, Joachim Seemann, Joseph L. Goldstein et al. · Proceedings of the National Academy of Sciences · 2007 · 291 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17