Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Jay D. Horton, Joseph L. Goldstein, Michael S. Brown · Journal of Clinical Investigation · 2002 · 4K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

Joyce J. Repa, Guosheng Liang, Jiafu Ou et al. · Genes & Development · 2000 · 1.7K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

Jay D. Horton, Nila Shah, Janet A. Warrington et al. · Proceedings of the National Academy of Sciences · 2003 · 1.4K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

Xiaodong Wang, Ryuichiro Sato, Michael S. Brown et al. · Cell · 1994 · 1K citations

Life Sciences, Biochemistry, Molecular Biology +8

Crucial Step in Cholesterol Homeostasis

Tong Yang, Peter J. Espenshade, Michael E. Wright et al. · Cell · 2002 · 984 citations · Full text

Life Sciences, Biochemistry, Cell Biology +14