Concepedia

EFLA 945 restricts AIM2 inflammasome activation by preventing DNA entry for psoriasis treatment

I‐Che Chung, Sheng-Ning Yuan, Chun‐Nan OuYang, Sheng-I Hu, Hsin‐Chung Lin, Kuo‐Yang Huang, Wei‐Ning Lin, Yu-Ting Chuang, Yu-Jen Chen, David M. Ojcius,

Cytokine · 2019 · 34 citations · 24 references

DOI

Concepts

References

24

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi, Yue Zhao, Kun Wang et al. · Nature · 2015 · 6.5K citations

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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Veit Hornung, Andrea Ablasser, Marie Charrel-Dennis et al. · Nature · 2009 · 2.6K citations · Full text

, , +11

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

Leslie van der Fits, Sabine Mourits, Jane S.A. Voerman et al. · The Journal of Immunology · 2009 · 2.1K citations · Full text

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Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

Caroline E. Sutton, Stephen J. Lalor, Cheryl Sweeney et al. · Immunity · 2009 · 1.5K citations · Full text

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Generation of pathogenic TH17 cells in the absence of TGF-β signalling

Kamran Ghoreschi, Arian Laurence, Xiang‐Ping Yang et al. · Nature · 2010 · 1.4K citations

, , +14